Apoptosis-Enhancing Nuclease Proteins

Protein Information

Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.

Synonyms

2700083B06Rik; AEN; aen {ECO:0000250; apoptosis enhancing nuclease; Apoptosis-enhancing nuclease; apoptosis-enhancing nuclease {ECO:0000250; interferon stimulated exonuclease gene 20kDa-like 1; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1; interferon-stimulated 20 kDa exonuclease-like 1 {ECO:0000312; ISG20L1; pp12744; RGD:1305051}; RGD1305051; SBBI58; UniProtKB:Q8WTP8}